Suffering from Excess Histamine?

Strengthen the body's defenses against histamine, naturally

Allergens are typically harmless, but for some they can cause excess histamine release. Histamine Shield Plus can naturally strengthen the body's defenses against histamine and help normalize the body's response to allergens.


What Does Excess Histamine  Cause?

  • Runny nose
  • Congestion
  • Watery eyes
  • Sneezing
  • Coughing
  • Itchy eyes

Why Does the Body Create Excess Histamine?

  • Mast cells, immune cells abundant in the sinuses, store histamine
  • Histamine is important for immune function and wakefulness
  • Histamine benefits the body but, excess histamine causes discomfort.
  • For some, typically harmless allergens cause mast cells  to become unstable
  • Mast cells degranulate, release stored histamine, and cause excess histamine

How Histamine Shield Plus Works

5 Effective Histamine and Mucus Fighters in 1
  • Quercitin

    Quercitin helps to stabilize mast cells
  • Stinging Nettle

    Shown to inhibit the enzyme that contributes to mast cell degranulation
  • Vitamin C

    Vitamin C is able to deactivate histamine
  • Bromelain

    Bromelain enhances the absorption of quercitin and breaks down allergens.
  • N-Acetyl Cysteine

    Reduces mucus viscosity for more effective clearance

Comprehensive support

Curated by Health Professional

NonDrowsy and  No Dryness


Full-Potency Ingredients 

Fair and Honest Pricing

NonGMO + Gluten Free

Histamine Shield Plus

Natural   |   Comprehensive   |   Strong

Defend Against Excess Histamine, Naturally

Shield the body from excess histamine. Histamine Shield Plus is a targeted blend of natural flavonoids, antioxidants, enzymes, and botanicals designed to provide comprehensive support for seasonal and environmental allergens.

At WellSource Nutraceuticals, we believe in effective products at fair and honest pricing. We stand behind the quality and value of our products.

Similar Quality Products: $76.95 
Histamine Shield Plus MSRP: $58.99
What You'll Pay Today: $39.99 + Free Shipping  

Histamine Shield Plus 120CT All Natural Antihistamine Supplement, D-Hist® Affordable Alternative

Our Testimonials

What People Say

This is by far one of the best product for all-over sinus and allergy support that I’ve ever encountered

James Tasker

I can really tell a difference in the congestion that I normally have due to allergies. I’m thrilled!

Mary Lou Rosen

I had no idea just how great it feels to live absolutely symptom-free again, until I had it back in my life!

Emily Andrews

Customer Reviews

Based on 52 reviews
Phil Rollhauser

Great product.

Works great!

This supplement works great for allergies and stopping post nasal drip.

This Stuff Really Works!

I don't write many online reviews but this stuff really works. I have been taking it for about a month. Before that I was sneezing a lot. This morning I decided not to take it. Now all of the sudden this afternoon I am sneezing again. I have never had allergies before and do not know the cause of the sneezing but a month ago I decided to try this product and as I already said -- it really works! I take one in the morning and one before bed and within a day or two of starting the product -- the sneezing completely stopped UNTIL I decided to skip my pill this morning. Won't be doing that again!

Monica Fuentes
Safe and super effective

I used to buy a brand for twice the price with the exact ingredients. These work just the same. We live in Texas where allergies are just crazy. They help significantly for my son who suffers the most. When allergy season hits hard he takes these twice a day. (He’s 13, BTW) And the fact that they are natural, helps me feel a whole lot better.


If I could give this 100 stars I would! I can't begin to say how ultimately pleased I am with this! I have Dog, Cat, and Dust Mite Allergies. I did allergy shots for 5 years and daily took Zyrtec D in the morning and Zyrtec in the evening and still dealt constantly with flare-ups. I read some alarming things about Zyrtec and quit. This product has changed my life! I don't take Zyrtec and don't do injections any more. I did follow their directions and did the Load Dosing of 2 capsules 3 times a day for a week, and am now on a maintenance dose of 2 capsules a day. I no longer experience flare-ups at all. I sleep better and am not constantly congested or having headaches. This is AMAZING stuff & I am so grateful!!

Frequently Ask Questions

Is this product nonGMO and gluten free?

Yes. Histamine Shield Plus is also free of soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners or preservatives.

How do I take Histamine Shield Plus?

2 capsules three times per day for 7-10 days or as recommended by your health care professional.

2 or more capsules per day or as recommended by your health care professional.

Will this product make me sleepy, cause dryness, or cause any other side effects?

The active ingredients in Histamine Shield Plus are all natural, and won't cause drowsiness, dryness, or any other side effects experienced by other products.

Who is WellSource Nutraceuticals?

WellSource Nutraceuticals specializes in the research, formulation, and distribution of innovative quality products which are supported by science to improve quality of life. The company’s executive management team is composed of industry veterans – pharmacists, physicians, nurses, and scientists with decades of experience.

Where is WellSource Nutraceuticals located?

WellSource Nutraceuticals is located in the Purdue Research Park of Northwest Indiana, which is managed by the Purdue Research Foundation.

Why are WellSource Nutraceuticals products so effective?

  • We believe in better patient outcomes and challenging traditional practices.
  • We believe in challenging traditional practices by offering products that are sourced from:
    • The highest quality ingredients.
    • Manufactured in state-of-the-art FDA registered laboratories right here in the United States that adhere to our stringent Quality Assurance Standards for safety, efficacy, as well as cGMP and NSF supplement quality standards.
    • Ensuring all of WellSource’s products are subjected to numerous quality tests and assays throughout the manufacturing process to verify purity and full potency.
  • We believe that it is our responsibility to lead in delivering quality products consistent with the latest scientific research and innovation.
All of this allows us to bring our consumers vitamins and supplements of unrivaled excellence in quality and value.
These statements have not been evaluated by the US Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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